Jim Green
Jim's Latest Interactions
I get the impression that Parkinson's disease can be cured now with nutraceuticals. In particular, Parkinsonian tremors can be eliminated with Ashwaganda. Searc Internet papers, patents, and books for complete details and see Life Extension Magazine for a search on Parkinson's Disease.
I finally broke a bone, after 71 years, 3 bones, all told. The right femur, the right tibial plateau, and the 4th metacarpal bone in the left hand. Aftter 9 weeks i can get into a walker and go from a robotic bed to the commode and back, or transfer to and from a wheel chair.
Perhaps I damaged the ligament joining the left ulna at the wrist to the radius bone. In the walker, i can let go and stand erect on both feet. I am doing a a few 2-legged walking exercises in the walker. I may need a cane for while. I am uncertain about the condition of the meniscus shock absorber protecting articular cartilage at the condyles of the femur and the tibia. Without the meniscus or a replacement for it, arthritis develops. I may need to tape my left wrist after the cast is removed from my left arm.
On my way to my surgeon's office and back our van picked up Rich Fagg. Rich was recovering from violence in Chicago leading to a fall of two stories. He was also in a
wheel chair. Both of us were in A Man for All Seasons at North High in the 66-67 school year, I as the Duke of Norfolk, he as Sir Thomas Moore. I have not seen him since that ride,
In which he seemed to be a radio full of bright brainwaves. It reminded me of Joni Mitchell's song You Turn Me On, I'm a Radio.
See Sally Sanchez Guevara obiturary at Legacy.com:
https://www.legacy.com/obituaries/name/sally-sanchez-obituary?pid=195465900 .
See Darrell Duncan's online obituary and video material at
https://www.smithfamilymortuaries.com/memorials/darrell-duncan/4100564/ .
The 1st photo was taken at calendar age 70.33 at my apartment near WSU.
I tried fasting for 3 days to get SIRT6 up for DNA and telomere repair, followed
by 3 more days of hard exercise with HGH boosters to lengthen telomeres
and came up with the 2nd photo on Halloween, 2019, after 3 six-day cycles of this.
See www.lef.org/magazine for details of how not to die of old age, but to get young again.
Joseph Damilini was probably the good mailman that saw that the mail was faithfully delivered. I mean, we have recently seen the opposite thing, for a decade or two, even. I wish the mail were as faithfully delivered as it was back in the 20th Century, before the Twin Towers hit of 2001. Perhaps this has recently improved again.
Happy Birthday this coming Sunday, September 1, 2019, Darwin.
I hope the cold wind blowing in over Lake Michigan will not make
you feel too much like Frankenstein on an ice flow, but that you have
a warm camp to tidy up in and friends, too. It was a pleasure having you in
Thespians back in the 60s for time in staged dramas and comedies. Many thanks
to you and Rich Fagg for inviting me to join it. Thespians made life more romantic.
Liga Valdmanis (class of 1966) blessed me with a copy of The Rubiyat of Omar Khayyam for my
bookshelves; Barbara Pelley (class of 1966) taught me secrets of necking all the way to A Hard Day's Night (1964) one evening in a snowstorm to the tune of I Should Have Known Better. I might have missed young love in gymnastics. Thespians made me a happier, more sociable man. I looked forward to cast parties.
Afterwards as a student at KU in Lawrence was to the tune of Scarborough Fair, April Come She Will,
and Flowers Never Bend with the Rainfall with numbers from Judy Collins and the
great English-speaking bands of the 1970s, though KU coursework was more like
soaring with Beethoven's 3rd and 9th symphonies as one picked up skills that promote
insight and optimism. I graded papers for a senior course in electromagnetic theory, ran projectors for the campus film service, took coursework in electronics for the psychology lab, and took graduate courses in quantum mechanics and nuclear physics. Higher education and romance was there, as Viet Nam war reports streamed past on television against a partly psychedelic background with many overflowing bookstores.
Don't miss http://www.lef.org/magazine and similar anti-aging journals.
Photo: Jim Green at 70+ in the Summer of 2019 at Ablah Library,
equipped with perfectly 20/20 lenses, although I'm cleared to drive
in Kansas without them. I interviewed at Bell Labs in Chicago in
1977 after getting an MSEE at WSU and got a job offer from there, but went with a different outfit.
The winds from the lake were very cool even in the Summer.
Photos, July 2019, age 70 years, 2 months. Working on rejuvenation with techniques
from regenerative medicine. Tissue-regenerative vitamin A (retinol) is taken 50 caps/day
of 8000 IU softgels. This amounts to half a bottle of Nature Made Vitamin A softgels
per day. Twice as much can put cramps in my hands. I also get 15 mg/day of
neuroregenerative vitamin B12 in 3 5000 mcg tablets. This prevents Alzheimer's Disease
from vitamin B12 deficiency, and can even enlarge the brain. I also take the telomerase activator astragalus powder at 30 grams to 33 grams per day for perhaps 2/3 of each month, the old maximum dose of astragalus in Chinese medicine. I do it by ordering a tall coffee mixed with sweetener and flavored cream, into which I mix 60 to 66 caps of astragalus powder from Nature's Way astragalus caps (500 mg/ea) or Natural Foods
(500 mg/ea), until all the gelatin caps are dissolved and a smooth suspension of astragalus powder in flavored coffee is obtained. This is really the Shangri-La stuff that works, although rejuvenation times at these dosages runs at about -5 years/year, so that it takes 4 years to de-age yourself 20 years at this dosage. Astragalus modifies telomere length to increase the number of cell divisions in a cell, but is more effective for some classes of cells than others. It is best of all for Natural Killer cells immune system that detect cancerous cells and destroy them. It seems that perhaps the NK cells attack and
destroy senescent cells exhibiting cell surface alterations suggestive of a precancerous cell to the immune system. The true upper limit for astragalus seems to be about 4x the
dosage quoted above, according to recent Chinese papers on the matter. Faster deaging
with astragalus may be possible with astragalus or astragalus extract than expected using
these higher dosages above 33 grams/day of astragalus powder or above 11 grams per day of
astragalus extract. I also take Life Extension skin-restoring ceramides that glue rising new
skin cells together better as they rise, so that the skin is better sealed and hydrated. To get hair color back from the roots out, one can rub 2 bottles of liquid astragalus extract into the scalp each month for a year or two. The first experiments showing this were
done years ago at Stanford University. There are also popularly available medicines
at health food stores and the supermarket that can be used to defeat all of the
known causes of death from disease and aging. For instance, I take pomegranate juice, which deflects atherosclerosis (the major killer of Americans). See Life Extension Magazine at
http://www.lef.org/magazine for details. Thus, physiological immortality with rejuvenation
included seems to be right around the corner on Internet these days and I think we
can be more optimistic about the future as long as we eat carefully, take our medicine,
and exercise to acquire optimum condition while reviewing the associated literature with care.
So pack up your troubles in your old kit bag and smile, boy, smile.
Garlic [Index, Garlic as telomerase activator (178), Wikipedia, WebMD/Garlic, LifeExtension,
Garlic Central, Jen Reviews/Garlic,
Links/Garlic, Images, Video, Papers, Patents, Books, LEF;
Links/Crushed garlic as an antibiotic, Images, Video, Papers, Patents, Books, LEF;
Links/anticancer garlic, Images, Video, Papers, Patents, Books,
Links/Garlic suppresses atherosclerosis, Images, Video, Papers, Patents, Books, LEF;
Links/Crushed garlic as a platelet aggregation inhibitor, Images, Video, Papers, Patents, Books, LEF;
Links/Garlic as an antioxidant, Images, Video, Papers, Patents, Books, LEF;
Links/Garlic as a Vasodilator, Images, Video, Papers, Patents, Books, LEF; Vasodilators.
Links/Allicin as a Vasodilator, Images, Video, Papers, Patents, Books, LEF; Vasodilators.
Links/Garlic and NK cell activity enhancement, Papers, Patents, Books, LEF; NK Cell Activity Enhancers;
Links/Garlic as a platelet aggregation inhibitor, Papers, Patents, Books, LEF; Platelet Aggregation Inhibitors;
Papers/garlic and telomere lengthening; Genital Warts; toxicity, dosage; Recipes/Garlic;
Garlic History (Links, Images, Video, Papers, Patents, Books, LifeExtension); Allicin,
AMPK activators/Garlic; Antibiotics, Antioxidants, Anti-inflammatory nutraceuticals, Apoptosis Inducers/Garlic;
Fibrinogen, More…
Food | Quercetin Content |
Remarks |
NOW Quercetin with Bromelain | 800 mg/cap | Contains 800 mg per capsule quercetin, a senolytic drug, plus 160 mg per cap bromelain, a fibrolytic protease that attacks atherosclerotic plaque, inhibiting angina, heart attack, and stroke, also being a platelet aggregation inhibitor inhibiting blood clot thrombus, a primary cause of death in patients over 50. |
Capers | 180 mg/100g | 28.349523 grams/oz, 1 oz = 1/16 lb. 3.53 oz per 100 grams, or 0.22 lb per 100 g. |
Lovage Leaves | 170 mg/100g | Loveage is a member of the parsley family. |
Elderberries | 42 mg/100 g | Elderberries contain high amounts of quercetin |
Red Onions | 19.93 mg/100g | . |
Onions | 19.36 mg/100g | We find 25.94 mg of quercetin per (1/2 cup) onion (small onion). |
Green Hot Peppers | 15 mg/100g | . |
Kale | 7.71 mg/100g | . |
Spinach | 4.86 mg/100g | . |
Apple | 4.4 mg/100g | A large red apple contains about 10 mg of quercetin. |
Red Grapes | 3.54 mg/100g | . |
References
[1] Butt MS, Sultan MT, Butt MS, Iqbal J. (2009),
Garlic: nature’s protection against physiological threats,
Crit Rev Food Sci Nutr 2009 Jun;49(6):538-51. [Papers/Garlic protection, Books]
[2] Ishikawa H, Saeki T, Otani T, et al. (2006),
Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer,
J Nutr 2006 Mar; 136(3 Suppl):816S-20S. [Special/NK Cell boosters].
[3] Svendsen, L., Rattan, S.I., Clark, B.F. (1994),
Testing garlic for possible anti-ageing effects on long-term growth characteristics, morphology and macromolecular synthesis of human fibroblasts in culture [Abstract],
Journal of Ethnopharmacology, (1994 July 8) 43(2):125-33. Reference by [4].
[4] Garlic, Nature's Perfect Prescription, by C. G. Hullquist, page 69.
[5] Borek C (2006),
Garlic reduces dementia and heart-disease risk,
J Nutr 2006 Mar;136(3 Suppl):810S-812S. [Dementia, Cardiovacular Disease].
[6] Campbell JH, Efendy JL, Smith NJ, Campbell GR (2001),
Molecular basis by which garlic suppresses atherosclerosis [PDF],
J Nutr 2001 Mar;131(3s):1006S-9S. [Atherosclerosis].
[7] Efendy JL, Simmons DL, Campbell GR, Campbell JH (1997),
The effect of the aged garlic extract, ‘Kyolic’, on the development of experimental atherosclerosis,
Atherosclerosis 1997 Jul 11;132(1):37-42. [Aged Garlic Extract, Kyolic].
[8] H.F Lua, C.C Sueb, C.S Yuc, et al (2004),
Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells.
___[Bladder Cancer, Diallyl disulfide, Caspase-3 activated apoptosis].
[9] Oommen S1, Anto RJ, Srinivas G, Karunagaran D (2004),
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells [Abstract, PDF],
Eur J Pharmacol 2004 Feb 6;485(1-3):97-103.
___[Apoptosis, Caspase-mediated Apoptosis (Patents, Books, LEF)].
___[Links/Allicin, Images, Papers, Patents, Books, LEF].
"Garlic (Allium sativum) has been used for centuries for treating various ailments, and its consumption is said to reduce cancer risk and its extracts and components effectively block experimentally induced tumors. Allicin, the major component present in freshly crushed garlic, is one of the most biologically active compounds of garlic. We found that allicin inhibited the growth of cancer cells of murine and human origin. Allicin induced the formation of apoptotic bodies [Links], nuclear condensation [Links] and a typical DNA ladder [Links] in cancer cells. Furthermore, activation of caspases -3, -8 and -9 and and cleavage of poly(ADP-ribose) polymerase were induced by allicin. The present results demonstrating allicin-induced apoptosis of cancer cells are novel since allicin has not been shown to induce apoptosis previously. Our results also provide a mechanistic basis for the antiproliferative effects of allicin and partly account for the chemopreventive action of garlic extracts reported by earlier workers."
The paper investigates allicin-induced apoptosis in cervical cancer cells [Apoptosis/Cervial Cancer] and colon cancer cells [Apoptosis/Colon Cancer], and quotes results for diallyl disulfide-induced apoptosis in leukemia [Apoptosis/Leukemia] cells. |
[10] Guo, N.L., Lu, D.P., Woods, G.L., Reed E., Zhou, G.Z., Zhang L.B., Waldman, R.H. (1993),
Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro,
Chin Med J (Engl) (1993 Feb), 106(2):93-6. [Garlic cures CMV (Papers, Books, LEF); CMV]
[11] Moriguchi, T., Takashina, K., Chu, P.J., Saito, H., Nishiyama, N. (1994),
Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract [PDF], Biol Pharm Bull (1994 Dec) 17(12):1589-94.
"Chronic feeding of raw garlic causes anemia, weight loss, and failure to grow."
[12] Vinay K Singh, Dinesh K Singh (2008),
Pharmacological Effects of Garlic (Allium sativum L.) [PDF],
ARBS Annual Review of Biomedical Sciences,
Department of Zoology, DDU Gorakhpur University, Gorakhpur, U.P., INDIA
Received: 11 September 2007; accepted 21 January 2008.
"The half-life of allicin (concentration of 0.1-0.4 mg/ml) at room temperature is 10 days in 1 mM citric acid (pH 3), 4 days in water, 48 h in methanol or chloroform, 24 h in ethanol, 24 h in hexane and 3 h in ether (Lawson, 1993)". Evidently, allicin should be freshly prepared from crushed garlic. |
[13] Stephen Laifer (2005),
Garlic [OnLine],
Life Extension Magazine April 2005.
___Links/Garlic, Images, Video, Papers, Patents, Books, LEF.
[14] Riddle JM (2001),
Garlic’s history as a medicine,
Paper presented at: American Herbal Products Association International Garlic Symposium, July 31, 2001.
___Garlic History (Links, Images, Video, Papers, Patents, Books, LifeExtension).
[15] Carmia Borek, Ph.D. (2000),
Garlic, the Bountiful Bulb [Online],
Life Extension Magazine January 2000.
[16] Tilli CM, Stavast-Kooy AJ, Vuerstaek JD, et al. (2003),
The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis,
Arch Dermatol Res 2003 Jul;295(3):117-23. [Apoptosis/Garlic, Ajoene (Papers, Patents, Books, LEF), Skin Cancer].
[17] Rana SV , Pal R , Vaiphei K , Singh K (2006),
Garlic hepatotoxicity: safe dose of garlic, [OnLine],
Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation [2006, 27(1):26-30].
__[Garlic hepatotoxicity (Papers, Patents, Books, LEF); Safe Dose of Garlic (Books, LEF)].
__" 1.0, 2.5 and 5.0 g/kg body weight/day of garlic showed significant (P<0.001) deterioration
__in liver function tests (LFT's) after 21, 14 and 7 days respectively."
__"Garlic with high dose has the potential ability to induce liver damage and
__low doses (0.1 or 0.25 g / kg body weight/day) are safe doses of garlic."
__0.5 g/kg body weight/day dose of garlic showed morphological changes in the liver of one rat after 29 days.
__200 lb. = 90.7185 kg. 0.1 g/kg x 90.7185 kg = 9.7185 grams, 0.25 g/kg x90.7185 kg = 24.29625 g.
__0.5 g/kg x 90.7185 kg = 45.35925 grams.
__The average supermarket clove of garlic weighs about 4-7 grams.
__Exception: A typical garlic clove weighs about 3 grams. - How to Use Garlic Medicinally.
__Confirmation of 3 grams/clove of garlic.
__Google Search: Weight of a garlic clove in grams.
__Google Search: Safe dose of garlic (Papers, Patents, Books, LEF).
[18] Vinay K Singh, Dinesh K Singh (2008),
Pharmacological Effects of Garlic (Allium sativum L.),
ARBS Annual Review of Biomedical Sciences, 7 February 2008.
"Chinese strongly believe that garlic prolongs longevity (Srivastava et al., 1995) and is useful in treating most human diseases, including infections, cancer and heart diseases."
|
[19] Morbidoni L, Arterburn JM, Young V, Mallins D, Mulrow C, Lawrence V (2001),
Garlic: its history and adverse effects,
J Herbal Pharmacother 2001;1:63-83.
___Garlic History (Links, Images, Video, Papers, Patents, Books, LifeExtension).
___(Links/Adverse Effects of Garlic, Images, Video, Papers, Patents, Books, LifeExtension).
Abstract: "Garlic is a popular herbal alternative therapy. Adverse effects of garlic that have been reported with oral ingestion, inhalation, and topical exposure include smelly breath, body odor, flatulence, esopha-geal and abdominal pain, small intestinal obstruction, contact dermatitis, rhinitis, asthma, bleeding, myocardial infarction, urticaria, angioedema, anaphylaxis, skin blisters, and ulcero-necrotic lesions. Causality of garlic for specific adverse effects is best established for smelly breath, body odor, and allergic reactions; data regarding other adverse effects are primarily based on case reports. The frequency of adverse effects of garlic and whether they vary by particular preparations are not established."
|
[20] Doug Casey (2006),
The Virus Killer They Don't Want You to Know About,
InvestorsInsight.com, 04-18-2006.
"These are garlic's amazing health benefits: It kills every virus, bacterium, fungus, and amoeba known to man--without the risk of creating resistance. It can be used as prophylaxis to prevent stomach ulcers and stomach cancer. It can prevent and successfully treat anthrax, dysentery, salmonella, staphylococcus, klebsiella, SARS, herpes, etc. Studies have found that it penetrates and kills cancer cells, without harming the healthy ones. It inhibits the formation of plaque on artery walls. It controls insulin levels and helps prevent weight gain." |
[21] Tariq H. Abdullah, O. Kandil, A. Elkadi, and J. Carter (1988),
Garlic Revisited: Therapeutic for the Major Diseases of Our Times? [PDF],
J Natl Med Assoc 1988 Apr; 80(4): 439–445.
[22] Rahman K (2003),
Garlic and aging: new insights into an old remedy,
Ageing Research Reviews [2003, 2(1):39-56].
"Garlic.... has been used throughout the history of civilization for treating a wide variety of ailments associated with aging. The role of garlic in preventing age-related diseases has been investigated extensively over the last 10-15 years. Garlic has strong antioxidant properties and it has been suggested that garlic can prevent cardiovascular disease, inhibit platelet aggregation, thrombus formation, prevent cancer, diseases associated with cerebral aging, arthritis, cataract formation, and rejuvenate skin, improve blood circulation and energy levels."
|
[23] Life Extension News (2016),
Aged garlic extract reduces arterial plaque burden,
Life Extension Magazine, May 2016.
___[Links/Aged garlic extract reduces arterial plaque burden, Papers, Patents, Books, Life Extension].
___[Links/Aged garlic extract, Papers, Patents, Books, Life Extension].
[24] * Journal of Nutrition 2016 Jan 13.
[25] There are species of garlic [Images, Books] that have larger cloves than others, so that the dosage [17] here must be qualified. Some bulbs of garlic may consist of as little as 3 cloves per bulb, for instance, while other species of garlic may have typically 8 cloves. Instead of 3-5 cloves/serving, perhaps half a bulb of garlic per serving would be a better way of specifying typical adult dose. I must get down to weighing it, too. Furthermore, the standard dose must be scaled down for children according to the child's bodyweight.
[26] http://www.livestrong.com/article/244977-the-benefits-of-eating-raw-garlic-cloves/ .
[27] K. C. Srivastava, A Bordia and S.K. Verma (1995),
Garlic (Allium sativum) for disease prevention,
South African Journal of Science February 1995.
[28] Lee T.y. and Lam T.H. (1991),
Contact dermatitis due to topical treatment with garlic in Hong Kong,
Contact Derm 24. 193-196.
[29] Lembo G., Balato N., Patrono C .• Auricchio L. and Ayala F. (1991),
Allergic contact dermatitis due 10 garlic (Allium sativum),
COlltacl Derm 25. 330-331.
[30] Febri B, Aiacbe I.M., Korbi S., Monkni M., Ben Said M, Memmi A .. Hizaoui B. and Boulref K. (1991),
Toxic effects induced by the repeated administration of Allium salivum,
L. J. Pharm. Belg 46,363-374.
[31] Rose K.D., Croissant P.D., Parliament e.F. and Levin M.B. (1990),
Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report,
Neurosurgery 26. 880-882.
[32] Elnima El., Ahmed S.A., Mekkawi A.G. and Mossa 1.S. (1983),
The antimicrobial activity of garlic and onion extracts,
Pharmazie 38, 747-748. [Onion Extracts, Onion].
[33] Abdulllah T. et al. (1989),
Enhancement of natural killer cell activity in AIDS with garlic,
Onkologie 21:52-53. [HIV, NK Cell Boosters].
[34] Block, E.(1985),
The chemistry of garlic and onion,
Sci Am 252: 114-119.
[35] Ide, N. and Lau, B.H. S. (1997),
Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein induced injury,
J Pharm Pharmacol 49: 908-911.
[36] Imai, J., Ide, N., Nagae, S., Moriguchi, T.,Matsuura, H. & Itakura, Y. (1994),
Antioxidants and free radical scavenge effects of aged garlic extract and its constituents,
Planta Med 60: 417-420.
[37] Kojima, R., Epstein, C.J. Mizui, T., Carlson, E. & Chan, P.H. (1994),
Protective effects of aged garlic extracts on doxorubicin-induced cardiotoxicity in the mouse,
Nutr Cancer 22:163-173.
[38] Lau, B.H. S. (1989),
Detoxifying, radioprotective and phagocyte-enhancing effects of garlic,
Int Nutr Rev. 9:27-31.
[39] Lawson, L.D., Ransom, D.K. & Hughs (1992),
Inhibition of whole blood platelet aggregation by compounds in garlic clove extracts and commercial garlic products,
Thromb Res 65: 141-156.
[40] Milner, J. A. (1996),
Garlic: Its anticarcinogenic and antimutagenic properties,
Nut Rev 54: S82-S-86.
[41] Moriguchi, T., Saito, H. & Nishyama, N. (1997),
Anti-aging effect of aged garlic extract in the inbred brain atrophy mouse model,
Clin. and Exp. Pharmachol. and Physiol 24: 235-242.
[42] Neil, H.A. et al.
Garlic powder in the treatment of moderate hyperlipidemia: a controlled trial and meta-analysis.
[43] Nishino, H.,Nishino,A.,Takayasu,A., Iwashima, Y.,Itakura,y., Kodera, Y., Matsuura, H.,& Fuwa, T. (1990),
Antitumorpromoting activity of Allixin, a stress compound produced by garlic,
The Cancer Journal 3:20-21.
[44] Numagami, Y., sato, S., & Onishi, T. (1996),
Nutritional and Health Benefits of Garlic as a Supplement Conference,
Neurochem Int 29: 135-143.
[45] Nutritional and Health Benefits of Garlic as a Supplement Conference,
Newport beach CA (1998). 1-70. Abstracts.
[46] Steiner, M. (1996),
A double blind cross over study in moderately hypercholesterolemic men that compare the effect of Aged Garlic Extract and placebo administration on blood lipids and platelet function,
Am. J. Clin. Nutr 64:866-870.
[47] Steinmetz, K.A., Kushi, L.H., Bostick, R.M., Folsom A.R & Potter, J.D. (1994),
Vegetables, fruit and colon cancer in the Iowa Women's Study,
Am. J. Epidemiol 139:1-5.
[48] Wei, Z. & Lau, B.H.S. (1998),
Garlic inhibits free radical generation and augments antioxidant enzyme activity in vascular endothelial cells,
Nutr. Res 18: 61-70.
[49] William Falloon (2015),
Major Advance In Slowing Aging,
Life Extension Magazine, February 2015.
[50] Guo L, Xie B, Mao Z. (2012),
Autophagy in Premature Senescent Cells Is Activated via AMPK Pathway,
Int J Mol Sci 2012;13(3):3563-82. [AMPK].
[51] Rubinsztein DC, Mariño G, Kroemer G. (2011),
Autophagy and aging,
Cell 2011 Sep 45. 2;146(5):682-95. [AMPK].
[52] Amagase, H., Schaffer, E.M.,& Milner J. (1996),
Dietary components modify the ability of garlic to suppress 7,12,-dimethyl (a anthracene induced DNA adducts),
J. Nut 126:817-824.
[53] Freeman, F. & Kodera, Y. (1995),
Garlic Chemistry: Stability of S-(2-Propenyl) 2-Propene-1-sulfinothioate (Allicin) in blood, solvents and simulated physiological fluids,
J. Agr. and Food Chemistry 43:2332-2338.
[54] Heber D (2004),
Vegetables, fruits and phyto-estrogens in the prevention of diseases,
J Postgrad Med 2004 Apr;50(2):145-9.
[55] Atmaca G (2004),
Antioxidant effects of sulfur-containing amino acids,
Yonsei Med J 2004 Oct 31;45(5):776-88.
[56] Kempaiah RK, Srinivasan K (2004),
Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats, Ann Nutr Metab 2004 September ;48(5):314-20. [Curcumin, Capsaicin].
[57] Kempaiah RK, Srinivasan K (2004),
Antioxidant status of red blood cells and liver in hypercholesterolemic rats fed hypolipidemic spices,
Int J Vitam Nutr Res 2004 May;74(3):199-208.
[58] Perez-Severiano F, Rodriguez-Perez M, Pedraza-Chaverri J, et al. (2004),
S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats, Neurochem Int 2004 Dec;45(8):1175-83.
[59] Maldonado PD, Barrera D, Rivero I, et al. (2003),
Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage,
Free Radic Biol Med 2003 Aug 1;35(3):317-24.
[60] Sovova M, Sova P (2004),
Pharmaceutical importance of Allium sativum L. 5. Hypolipemic effects in vitro and in vivo,
Ceska Slov Farm 2004 May;53(3):117-23.
[61] Durak A, Ozturk HS, Olcay E, Guven C (2002),
Effects of garlic extract supplementation on blood lipid and antioxidant parameters and atherosclerotic plaque formation process in cholesterol-fed rabbits,
J Herb Pharmcother 2002;2(2):19-32.
[62] Budoff MJ, Takasu J, Flores FR, et al. (2004),
Inhibiting progression of coronary calcification using aged garlic extract in patients receiving statin therapy: a preliminary study, Prev Med 2004 Nov;39(5):985-91.
__[Links/Coronary Calcification (Papers, Patents, Books, LEF), Vascular Calcification].
[63] Wilburn AJ, King DS, Glisson J, Rockhold RW, Wofford MR (2004),
The natural treatment of hypertension,
J Clin Hypertens (Greenwich) 2004 May;6(5):242-8. [Hypertension].
[64] Durak I, Kavutcu M, Aytac B, et al. (2004),
Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol, J Nutr Biochem 2004 Jun;15(6):373-7.
[65] Sengupta A, Ghosh S, Bhattacharjee S (2004),
Allium vegetables in cancer prevention: an overview,
Asian Pac J Cancer Prev 2004 Jul;5(3):237-45. [Cancer].
[66] Hassan HT (2004),
Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy,
Leuk Res 2004 Jul;28(7):667-71.
__[Ajoene (Papers, Patents, Books, LEF), Leukemia (Papers, Patents, Books, LEF)].
[67] Ledezma E, Apitz-Castro R, Cardier J (2004),
Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin,
Cancer Lett 2004 Mar 31;206(1):35-41.
__[Ajoene (Papers, Patents, Books, LEF), Melanoma (Papers, Patents, Books, LEF)].
[68] Tilli CM, Stavast-Kooy AJ, Vuerstaek JD, et al. The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis,
Arch Dermatol Res 2003 Jul;295(3):117-23.
__[Ajoene (Papers, Patents, Books, LEF), Basal Cell Carcinoma (Papers, Patents, Books, LEF)].
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Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells,
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__[Ajoene (Papers, Patents, Books, LEF), Proteasomes, Leukemia].
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Food Chem Toxicol 2004 Oct;42(10):1543-52.
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Garlic Searches:
Garlic promotes HDL cholesterol and lowers total cholesterol.
Carcinogenic Viral pathogens [Papers, Patents, Books, LifeExtension] may cause cancer (although 80% of cancers are not from viruses):
___Adenovirus, a tumor provirus (DNA genome 36 kbp) [Micklos, et.al, DNA Science, p.225].
_____Adenovirus causes only flu-like symptoms in humans, but develops malignancies in mice.
___Epstein-Barr virus can cause lymphoma.
___Hepatitis B virus (DNA genome 3 kb) can cause liver cancer in 10-20% of chronic infections,
___Hepatitis C virus (RNA genome 10 kb) can cause liver cancer in 5% of chronic infections,
___HTLV-1 virus can cause lymphoma or adult T-cell leukemia via the viral gene tax.
___Herpes viruses can cause Burkitt's lymphoma, nasopharyngeal cancer, and Kaposi's sarcoma.
___HIV virus leads to higher rates of lymphomas and Kaposi's sarcoma via immunosuppression.
___Papilloma virus [Images] (DNA genome 8 kb) can cause cervical cancer.
___Polyomavirus, a tumor provirus, (DNA genome 5292 bp).
___Rabbit fibroma virus.
___Rous sarcoma virus (RSV) (DNA genome 60 kbp), a chicken tumor provirus.
___Simian virus 40 (SV40), a provirus, (DNA genome 5243 bp).
___T-cell lymphotropic virus can cause lymphoma.
___Retroviruses (RNA-genome 9-10 kb) can cause adult T-cell leukemia [Encyclopedia].
___C-myc, if translocated by viral infection, may become unregulated and carcinogenic.
___Viral oncoproteins [Links, Images, Papers, Patents, Books] can cause cancer.
About 20% of human cancers are virus-induced, including anogenital cancers (papilloma viruses), liver cancer (hepatitis B virus and hepatitis C virus) and some lymphomas (Epstein-Barr virus and T-cell lymphotropic virus).
Heart Attack (Congestive Heart Failure)
[Index, Links, Images, Video, Video/What happens; Video/Heart Disease and Heart Attacks; 3D Animation, Papers, Patents, Books, LibCong, LifeExtension, Amazon, The Heart Scan Blog; Amyloidosis, Angina, Arjuna, Arteriosclerosis, Atherosclerosis, Atherosclerotic Plaque, Cardiology, Cardiovascular Disease, Cholesterol, C-reactive protein, Fats, Fibrinogen, Fibrolytic Proteases, Hawthorn, Homocysteine, Ischemia-Reperfusion Injuries, LDL Peroxidation, Lipid Peroxidation, Lycopene, Magnesium, Nattokinase, Oats, Platelet Aggregation Inhibitors, Serrapeptase, Smoking, Taurine, Thrombolytic Drugs, Uric Acid, Vascular Diseases, Vitamin D, Vitamin K2; Anemia anemia[1]] [73].
Cigarette smoking [Essay/Smoking, Index] is often seen in connection with heart attack. Smoking a pack of cigarettes a day more than doubles the risk of heart attack. The heart attack usually takes place when a blood clot forms in a small cardiac vessel feeding heart muscle narrowed by atherosclerotic plaque, typically after a piece of plaque breaks off in the progressively narrowing artery, jamming it and clotting up with an embolism after floating downstream. Myocardial infarction follows, killing heart cells near the artery deprived of oxygen.
Aspirin is recommended immediately to thin the blood and break up the clot. A more effective clot-busting injection may be used. Anticlotting agents and other blood thinners such as nitroglycerin may be taken. Fancy anticoagulants including warfarin (calcifies soft tissues like a sneak attack on warheads), heparins, fondaparinux or dabigatran work by blocking vitamin K1 or inactivating other clotting factors in the blood. See Platelet Aggregation Inhibitors and Thrombolytic Drugs. Antiplatelet thromboxane blockers such as aspirin, EPA and DHA from fish oil, dipyridamole, ticlopidine and clopidogrel prevent clotting by preventing thromboxane from rounding up clotting cells in the blood. Foods and nutraceuticals with blood-thinning effect [Papers, Patents, Books, LEF] (usually platelet aggregation inhibitors) include alfalfa, avocado, beer, bilberry, More…
(1) Interleukin 1-beta, targeted by DHA, upregulates the expression of adhesion factors in endothelial cells contributing to atherosclerosis. It is in the optimal range when IL-1-beta < 2.9 pg/mL. (2) Cyclooxygenase-2 (COX-2), an enzyme involved in prostaglandin production targeted by DHA and EPA, contributes to chronic inflammation and cardiovascular disease. COX-2 inhibitors include ibupofen and ginger and prescription drugs like Vioxx. Oleocanthol from extra virgin olive oil inhibits both COX-1 and COX-2 cyclooxygenases. However, inhibiting COX-2 enzymes can elevate levels of thromboxane A2 and leukotriene B4, so that continued use of COX-2 inhibitors may be dangerous. (3) Leukotriene B4 (synthesized from arachidonic acid and 5-lipooxygenase) and displaced from cells by DHA, induces vascular adhesion and inflammation of arterial and cardiac tissues. (4) TNF-alpha contributes to systemic inflammation (blunted by DHA and EPA) and stimulates the production of the vasoconstrictive endothelin-1, which can induce high blood pressure and long-term vascular damage. TNF-alpha concentrations should satisfy < 8.1 pg/mL. See vasodilators and TNF-alpha inhibitors. (5) Thromboxane (synthesized from omega-6 fatty acids [Index]) elevates blood pressure and is involved in blood clot formation, which may lead to fatal clots. Thomboxane activity is suppressed by EPA and DHA. |
"People with total omega-3 levels above 6.1% in their blood had a compelling 90% reduction in risk of sudden cardiac death [Images] compared to those whose omega-3s were 4.3% or less of their fatty acids." A 70% reduction in risk of death from heart attack [Images] was observed for people with EPA and DHA values of 4.6% or greater, when compared with those whose total values were less than 3.5%. 2000 mg to 4000 mg of fish oil per day may be required to obtain optimal cardiac defense [Papers, Patents, Books]. (See Julius Goepp, MD, "Optimize Your Omega-3 Status", Life Extension Magazine, May 2010). "Congestive heart failure responds favorably to taurine therapy." (Life Extension, Taurine), [36s] (k). In physical therapy, 3-5 grams of taurine [Encyclopedia, Images] is taken 30 minutes before exercise (9) and again just after.
Hawthorn extracts at 80 mg - 180 mg twice daily, and Arjuna bark powder at 500 mg every 8 hours are useful in preventing and reversing heart failures. Hawthorn extracts are termed cardiotonic because of their ability to improve heart muscle tone. Hawthorn extracts can improve coronary blood flow up to 70% and prevent ischemia-reperfusion injuries, reducing mortality rate in cardiac ischemia. Hawthorn extract substantially reduces arrhythmias that may follow or accompany ischemia and reperfusion, and pre-treatment prior to ischemia-reperfusion very substantially reduces the prevalence of deadly cardiac arrhythmias [Papers, Patents, Books] manifesting themselves as ventricular fillibration [Papers, Patents, Books] and heart flutter [Papers, Patents, Books].
Arjuna extracts [Encyclopedia] and extra virgin olive oil reduce total and LDL cholesterol, reduce trigycerides, and elevate HDL cholesterol, limiting atherosclerotic lesions in the aorta and improving endothelial function. Extra virgin olive oil and tomato soup lycopene reduce LDL peroxidation leading to atherosclerosis and consequently elevated hypertension. Two tablespoons of extra virgin olive oil in tomato soup makes antioxidant lycopene more bioavailable. See Silas Hoffman (2013), Novel Support for Chronic Heart Failure, Arrhythmia and Coronary Artery Blockage, Life Extension Magazine, Feb 2013. Cardiovascular problems may be reduced by taking green coffee bean extract at 350 mg before meals to reduce consequent elevated glucose. See William Falloon (2013), Preparing Your Body to Eat, Life Extension Magazine, Feb 2013.
Taurine Reduces Mortality Due to Congestive Heart Failure [Taurine].
"Congestive heart failure responds favorably to taurine therapy." (Life Extension), [36s] (k), [8], [9]. In animal studies, taurine reduced mortality due to heart failure by 80% [Ian Macleavy, 2013, LEF]. Taurine is abundant in fish.
References
[1] William Faloon (2009),
How to Circumvent 17 Independent Heart Attack Risk Factors,
Life Extension Magazine May 2009. [Heart Attack, Papers, Patents, Books, LEF; Fats, Oils].
[2] William Faloon (2009),
No More Heart Attacks!, Life Extension Magazine May 2009. [Heart Attack].
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___[AGEs, RAGE receptors, Endothelial Dysfuntion, Oxidative Stress, Diabetes].
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___[AGEs, RAGE receptors, Endothelial Dysfuntion, Oxidative Stress].
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___[AGEs, RAGE receptors, Endothelial Dysfuntion, Atherosclerosis].
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Live Longer By Changing How You Cook!,
Life Extension Magazine August 2015.
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Variability in response to cardiovascular drugs,
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___[Papers, Patents, Books, LEF].
___ursodeoxycholic acid (UDCA) [Papers, Patents, Books, LEF].
___Serious adverse consequences can result from a x2 overdose. Sensitive stuff.
___Can dissolve gallstones and atherosclerotic plaque. Natually occurring. See Ursodiol.
___RELATED: LEF search on arterial plaque dissolution produces:
___Serrapeptase 10 mg 90 capsules: Solaray, Item# 28548.(0) Retail Price: $24.99.
_____Serrapeptase [Papers, Patents, Books, LEF]. Silkworm's coccoon dissolving enzyme.
_______Serrapeptase for arterial plaque dissolution [Papers, Patents, Books, LEF].
_______Serrapeptase: The natural anti-inflammatory, Life Extension Magazine, September 2003.
[36] Nadia Mason (2014),
Focus on Serrapeptase [Online],
Discover Nutrition November 1, 2014.
" Because of its ability to dissolve fibrin, serrapeptase has also been used to dissolve arterial plaque, fibrous blockages in clogged or hardened arteries. As serrapeptase only dissolves dead or damaged tissue, this could enable the dissolution of harmful atherosclerotic plaques without causing any harm to the inside of the arteries. Studies of serrapeptase supplementation have found positive benefits with a dosage of around 10mg, taken after meals three times daily. No long-term studies of this supplement have yet been conducted, although studies to date suggest that supplementation for a period of 4 weeks seems safe (1,2)."
|
___Serrapeptase 10 mg 90 capsules: Solaray, Item# 28548.(0) Retail Price: $24.99.
_____Serrapeptase [Papers, Patents, Books, LEF]. Silkworm's coccoon dissolving enzyme.
_______Serrapeptase for arterial plaque dissolution [Papers, Patents, Books, LEF].
_______Serrapeptase: The natural anti-inflammatory, Life Extension Magazine, September 2003.
[37] Dr. H A Nieper - Germany (),
Silk Worm Enzymes For Carotid Artery Blockage [OnLine].
"Serapeptase is a stronger saseinolytic (fibrinolytic) agent than any other known alkaline or neutral protease such as bromelain or pronase."
___See Serapeptase as a fibrinolytic agent [Papers, Patents, Books, LEF].
___Bromelain as a fibrinolytic agent [Papers, Patents, Books, LEF; Index/Bromelain].
___Pronase as a fibrinolytic agent [Papers, Patents, Books, LEF].
[38] George E. Felton (1980),
Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients [Online],
Medical Hypotheses Volume 6, Issue 11, November 1980, Pages 1123-1133.
"Bromelain plasminogen activator will produce plasmin in rat experiments... Since bromelain therapy leads to formation of platelets with increased resistance to aggregation, it is obvious that the dominant endogenous prostaglandins being produced must be from the group that increases platelet cyclic AMP levels (prostacyclin, PGE1, etc.). The combination of fibrinolytic and antithrombic properties appear to be effective and two large scale tests on heart patients have shown a practically complete elimination of thrombosis."
|
[39] Pierro Francesco Di (2014),
Fibrinolytic compositions comprising bromelain and nattokinase for the prevention and treatment of phlebothrombotic states, WO 2014079689 A1, May 30, 2014.
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Surprising Factor Behind Sudden Cardiac Arrest,
Life Extension Magazine June 2015. [Testosterone, Magnesium].
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Greatest Threat to Longevity,
Life Extension Magazine January 2017. [Thrombosis, Thrombolytic Drugs].
[Arterial thrombosis (Typical disorders: Heart Attack, Ischemic Stroke);
Venous thrombosis (Typical Disorders: Deep Vein Thrombosis (DVT), Pulmonary Embolism)].
[63] Rosenschein U (2000),
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Arterial Plaque Rupture,
Life Extension Magazine May 2017.
___Gotu Kola improves the stability of soft atherosclerotic plaque
___by improving the expression of collagen.
___French maritime pine bark extract (150 mg) plus Gotu Kola (225 mg) improves soft plaque stability best.
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Should You Eat Before a Blood Test?,
Life Extension Magazine May 2017.
"Postprandial triglyceride-rich lipoproteins (such as VLDL cholesterol)" instigate "coronary plaque, carotid plaque, and aneurysms of the aorta."
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Dying From Neglect [OnLine],
Life Extension Magazine March 2002. [Encyclopedia, Anemia (Papers, Patents, Books, LEF)].
__"24% to 40% of hospitalized patients over age 65 are anemic [15]". __"...Blood deficient individuals have high mortality rates from diseases __such as heart failure, stroke and cancer." __"In (heart attack) patients with very low hematocrit (below 24%), __transfusion was associated with a 64% reduction in mortality. " __"Aging itself predisposes people to anemia." __"Stroke was the most common disease associated with anemia." __"The increased risk of mortality in cancer patients who were anemic was an astounding 65%!" __"Anemia sharply increases the risk that a heart attack victim will die within 30 days." Note that aplastic anemia often proceeds from an STD viral infection such as CMV, or other infections such as a candida yeast infection, all of them treatable with garlic. |
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Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B: the Copenhagen City Heart Study,
Arterioscler Thromb Vasc Biol 2007;27(3):661-70.
___Apolipoprotein B [Images, Papers, Patents, Books; Measuring Apolipoprotein B (Patents, Books)].
___Apolipoprotein B is a measure of all the cholesterol that is not HDL cholesterol.
[82] Lamarche B, Tchernof A, Moorjani S, et al. (1997),
Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study,
Circulation 1997;95(1):69-75.
[82] Wilkins JT, Li RC, Sniderman A, et al. (2016),
Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification: The CARDIA Study,
J Am Coll Cardiol 2016;67(2):193-201. [Vascular Calcification].
[83] Puri R, Nissen SE, Somaratne R, et al. (2014),
Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV),
Am Heart J 2016;176:83-92.
[84] Gouni-Berthold I, Berthold HK (2014),
PCSK9 antibodies for the treatment of hypercholesterolemia,
Nutrients 2014;6(12):5517-33.
[85] de Koning L, Malik VS, Kellogg MD, et al. (2012),
Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men,
Circulation 2012;125(14):1735-41, s1.
[86] Laakso M, Kuusisto J (2014),
Insulin resistance and hyperglycaemia in cardiovascular disease development,
Nat Rev Endocrinol 2014;10(5):293-302.
[87] Despres JP, Lamarche B, Mauriege P, et al. (1996),
Hyperinsulinemia as an independent risk factor for ischemic heart disease,
N Engl J Med 1996;334(15):952-7.
[88] Gerstein HC, Pais P, Pogue J, et al. (1999),
Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study,
J Am Coll Cardiol 1999;33(3):612-9.
[89] Hosszúfalusi N, Pánczél P, Jánoskuti L (1999),
Hyperinsulinemia Predicts Coronary Heart Disease Risk in Healthy Middle-Aged Men,
Circulation 1999;100(24):e118-e.
[90] Nadia Mason (2014),
Focus on Serrapeptase [Online],
Discover Nutrition November 1, 2014.
" Because of its ability to dissolve fibrin, serrapeptase has also been used to dissolve arterial plaque, fibrous blockages in clogged or hardened arteries. As serrapeptase only dissolves dead or damaged tissue, this could enable the dissolution of harmful atherosclerotic plaques without causing any harm to the inside of the arteries. Studies of serrapeptase supplementation have found positive benefits with a dosage of around 10mg, taken after meals three times daily. No long-term studies of this supplement have yet been conducted, although studies to date suggest that supplementation for a period of 4 weeks seems safe (1,2)."
|
___Serrapeptase 10 mg 90 capsules: Solaray, Item# 28548.(0) Retail Price: $24.99.
_____Serrapeptase [Papers, Patents, Books, LEF]. Silkworm's coccoon dissolving enzyme.
_______Serrapeptase for arterial plaque dissolution [Papers, Patents, Books, LEF].
_______Serrapeptase: The natural anti-inflammatory, Life Extension Magazine, September 2003.
[91] Dr. H A Nieper - Germany (),
Silk Worm Enzymes For Carotid Artery Blockage [OnLine].
"Serapeptase is a stronger saseinolytic (fibrinolytic) agent than any other known alkaline or neutral protease such as bromelain or pronase."
___See Serapeptase as a fibrinolytic agent [Papers, Patents, Books, LEF].
___Bromelain as a fibrinolytic agent [Papers, Patents, Books, LEF; Index/Bromelain].
___Pronase as a fibrinolytic agent [Papers, Patents, Books, LEF].
[92] Serrapeptase: The natural anti-inflammatory, Life Extension Magazine, September 2003.
Serrapeptase [Fibrolytic Proteases; Links/Serrapeptase, Papers, Patents, Books, LEF; Atherosclerosis].
Glioma
[Index, CMV, Viral Cures, Brain Cancer, Brain Cancer/Glioma, Wikipedia/Glioma, Links, Images, Video, Papers, Patents, Books; Images/glial cells, Images/glioma cancer cells, Images/glioblastoma; Links/Glioblastoma multiforme pathway, Images, Video, Qiagen/Glioblastoma multiforme pathway; Rare Diseases/Juvenile Pilocytic Astrocytoma, Links/Juvenile Pilocytic Astrocytoma, Images, Video, Papers, Patents, Books; Cancer; Carcinogens, Anticancer Nutraceuticals, Apoptosis, Apoptosis Inducers, Apoptosis Inducers/Glioma; Telomerase Inhibitors; Anticancer Telomerase Activators; Metastasis, NFkB, NFkB Inhibitors, Angiogenesis Inhibitors, Natural Killer cell boosters, Viral Cures].
Note that the HDAC inhibitors sulforaphane and sodium 4-phenylbutyrate have been used to induce apoptosis in glioma cancer cells. It may be true that other HDAC inhibitors [2] such as alpha lipoic acid and acetyl L-carnitine, often used to improve levels of Nerve Growth Factor (NGF), also have some effect against glioma.
Furthermore, capsaicin from red hot chili peppers suppresses tumors of the glioma type, and also induces apoptosis in glioma cancer cells. DHA induces apoptosis in neuroblastoma cells, and also protects normal neural cells from apoptosis. Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells [5].
Glioma Cancer cell apoptosis inducers: [Links, Images, Papers, Patents, Books, LifeExtension] ___Capsaicin suppresses tumors of the glioma type [3]. ___Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death [5]. ___DHA induces apoptosis in neuroblastoma cells, also protects normal neural cells from apoptosis. ___Sodium 4-Phenylbutyrate has been used to induce apoptosis in glioma cancer cells. ___Sulforaphane, also an HDAC inhibitor [2], induces apoptosis in glioma cells [1]. |
See Lisa Antone (2014), Common Virus Links to Deadly Brain Cancer More…
Animal Virus Family | Typical Member | Genome Size (kbp) | Cures showing antiviral activity |
DNA Genomes @ (replicate within the nucleus) |
. | . | . |
Herpesviruses [Index] | Cytomegalovirus (CMV) @ ___Glioma, ___Glioblastoma multiforme |
235 | Garlic [Encyc, Ref, Images], Glycyrrhizin [Index, Ref, Images], Natural Killer cell boosters, ___AHCC, ___Alpha Lipoic Acid, ___Arabinoxylin, ___Astragalus, ___Beta carotene, ___Chronic resistance exercise, ___Cistanche, ___Curcumin, ___Garlic, ___Genistein, ___Ginseng, ___Lentinan, ___Mistletoe, ___Modified arabinoxylan ______rice bran, ___N-Acetylcysteine, ___Resveratrol, ___Selenium, ___Shiitake Mushrooms, ___Vitamin B12 ______(Methylcobalmin), ___Vitamin C, ___Vitamin D3, ___Vitamin E, ___Zinc, Prescription Drugs: __Valganciclovir St. John's Wort [Index, Ref] _Hypericin from St.John's Wort. |
See Brain Cancer, Brain Cancer/Glioma and Apoptosis/Glioma for more details.
References
[1] Karmakar S, Weinberg MS, Banik NL, Patel SJ, Ray SK (2006),
Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane,
Neuroscience 2006;141:1265–80. [Glioma, Brain Cancer, Sulforaphane].
[2] Myzak MC, Karplus PA, Chung FL, Dashwood RH (2004),
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase,
Cancer Res 2004;64:5767–74. [Sulforaphane, HDAC inhibitors].
[3] Aggarwal BB, et al (2008),
Potential of Spice-Derived Phytochemicals for Cancer Prevention,
Planta Med 2008; 74: 1560–1569.
"...The potential of turmeric (curcumin), red chilli (capsaicin), cloves (eugenol), ginger (zerumbone), fennel (anethole), kokum (gambogic acid), fenugreek (diosgenin), and black cumin (thymoquinone) in cancer prevention has been established."
"...Chronic inflammation is a low level inflammation that can persist over 20–30 years; thus eventually leading to cancer. Perhaps the best-known markers of chronic inflammation include inflammatory cytokines [such as tumor necrosis factor (TNF), receptor activator for nuclear factor ? B ligand (RANKL), interleukins (IL-1, IL-6, IL-8)] and chemokines, inflammatory enzymes [cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), matrix metalloproteinase (MMP) and urokinase plasminogen activator (uPA)], adhesion molecules [intercellular adhesion molecule-1 (ICAM-1)], vascular cell adhesion molecule (VCAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and certain growth factors such as epidermal growth factor (EGF). Interestingly, all the mediators of inflammation are primarily regulated by two different transcription factors, nuclear factor kappa B (NF-?B) and signal transducer and activator of transcription-3 (STAT-3)." |
[4] Lisa Antone (2014),
Common Virus Links to Deadly Brain Cancer,
with preamble by William Faloon, Life Extension Magazine, February 2014.
[5] Kang SK, Cha SH, Jeon HG (2006),
Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells, Stem Cells Dev 2006;15(2):165-74. [Curcumin, Apoptosis Inducers/Curcumin, Apoptosis/Glioma].
[6] Sun L, Yoshii Y, Miyagi K, Ishida A. (1999),
Proliferation inhibition of glioma cells by vitamin K2,
No Shinkei Geka 1999 Feb;27(2):119-25. [Vitamin K2].
[7] Castriconi R, Daga A, Dondero A, et al. (2009),
NK cells recognize and kill human glioblastoma cells with stem cell-like properties,
J Immunol 2009 Mar 15;182(6):3530-9. [NK cells, NK Cell Activators]
[8] Fecci PE, Mitchell DA, Whitesides JF, et al. (2006),
Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma,
Cancer Res 2006 Mar 23. 15;66(6):3294-302.
[9] Roomi MW, Kalinovsky T, Rath M, et al. (2017),
Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells,
Oncol Rep 2017;37(3):1907-13. [Green Tea, Brain Cancer].
Atherosclerosis
[Wikipedia, Links/Atherosclerosis, Images, Video, Papers, Patents, Books, LifeExtension, LibCong; [1], [2];
Links/Foods most likely to produce atherosclerosis, Images, Video, Papers, Patents, Books;
Wikipedia/Atherogenesis, Links, Images, Video, Papers, Patents, Books;
Links/Atherogenic Lipoproteins, Images, Video, Papers, Patents, Books, LifeExtension;
The apolipoprotein B (apo B) blood test [Patents, Books, LEF] [310];
The LDL-P test [Patents, Books, LEF] [310];
Links/Endothelial dysfunction, Images, Video, Papers, Patents, Books, LifeExtension;
The History of Atherosclerosis and Its Treatment, Papers, Patents, Books;
Arginine, Arjuna, Atherosclerotic Plaque; Arteriosclerosis; Blood Tests; Cardiology; Cardiovascular Disease; Cholesterol, CoQ10 and atheroslerosis, CoQ10, Dementia, Endothelial Cells, Endothelial Dysfunction, Endothelial Senescence, Fats, Fibrolytic Proteases, Hawthorn, Heart Attack; Homocysteine, LDL peroxidation, Lipoprotein phospholipase A2 (Lp-PLA2), Lycopene, Macular Degeneration; Nitric Oxide; Oxidative Stress, Serrapeptase, Stroke, Testosterone, Ubiquinol, Vascular Calcification, Vitamin K2].
"Atherosclerosis, an inflammatory process in arterial walls, can lead to formation of plaques, whose rupture can lead to thrombus formation, obstruction of vessels (thrombosis), reduction of the blood flow (ischemia), cell death in the tissue fed by the occluded vessel, and depending on the affected vessel, to myocardial infarction or stroke." [3], More…
[97] Roger Alvarez (2016),
Slow the Progression of Atherosclerotic Plaque,
Life Extension Magazine February 2016.
[98] Thompson, Randall C et al.
Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations,
The Lancet, Vol 381, Issue 9873, 1211 - 1222.
__[The History of Atherosclerosis and Its Treatment, Papers, Patents, Books].
[99] Leskinen MJ, Kovanen PT, Lindstedt KA (2003),
Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells — a potential mechanism for the weakening and rupture of atherosclerotic plaques,
Biochem Pharmacol 2003;66(8):1493-8.
___[Activated Mast Cells, Activated Mast Cells in Atherosclerosis].
[100] Cheruvu PK, Finn AV, Gardner C, et al (2007),
Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study,
J Am Coll Cardiol 2007;50(10):940-9.
___[Thin-cap Fibroatheroma, Thin-cap Fibroatheroma and Ruptured Plaques].
[101] James JT, Dubery IA (2009),
Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban,
Molecules 2009;14(10):3922-41.
___[Medicinal triterpenoids from Centalla Asiatica].
[102] Incandela L, Cesarone MR, Cacchio M, et al (2001),
Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy,
Angiology 2001;52 Suppl 2:S9-13.
___[Centella Asiatica, Centalla Asiastica Supplements, Centella Asiatic and Treatment of Venous Insufficiency].
[103] Ivanov V, Ivanova S, Kalinovsky T, et al (2008),
Plant-derived micronutrients suppress monocyte adhesion to cultured human aortic endothelial cell layer by modulating its extracellular matrix composition,
J Cardiovasc Pharmacol 2008;52(1):55-65.
____[Nutraceuticals suppressing monocyte adhesion to arterial walls, Papers, Patents, Books, LEF].
[104] Incandela L, Belcaro G, Nicolaides AN, et al (2001),
Modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, randomized, placebo-controlled trial,
Angiology 2001;52 Suppl 2:S69-73.
[105] Cesarone MR, Belcaro G, Nicolaides AN, et al (2001),
Increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled, randomized trial,
Angiology 2001;52 Suppl 2:S19-25.
[106] Belcaro G, Maquart FX, Scoccianti M, et al (2011),
TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper,
Panminerva Med 2011;53(3 Suppl 1):105-18.
[107] D’Andrea G (2010),
Pycnogenol: a blend of procyanidins with multifaceted therapeutic applications?,
Fitoterapia 2010;81(7):724-36.
[108] Rohdewald P (2002),
A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology,
Int J Clin Pharmacol Ther 2002;40(4):158-68.
[109] Belcaro G, Dugall M, Hosoi M, et al (2014),
Pycnogenol and Centella Asiatica for asymptomatic atherosclerosis progression,
Int Angiol 2014;33(1):20-6.
[110] Luo H, Wang J, Qiao C, et al (2015),
Pycnogenol attenuates atherosclerosis by regulating lipid maetabolism through the TLR4-NF-kappaB pathway,
Exp Mol Med 2015;47:e191.
[111] Gu JQ, Ikuyama S, Wei P, et al (2008),
Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages,
Am J Physiol Endocrinol Metab 2008;295(6):E1390-400.
[112] Chistiakov DA, Revin VV, Sobenin IA, et al (2015),
Vascular endothelium: functioning in norm, changes in atherosclerosis and current dietary approaches to improve endothelial function,
Mini Rev Med Chem 2015;15(4):338-50.
[113] Fitzpatrick DF, Bing B, Rohdewald P (1998),
Endothelium-dependent vascular effects of Pycnogenol,
J Cardiovasc Pharmacol 1998;32(4):509-15.
[114] Enseleit F, Sudano I, Periat D, et al (2012),
Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study,
Eur Heart J 2012;33(13):1589-97.
[115] Hu S, Belcaro G, Cornelli U, et al (2015),
Effects of Pycnogenol on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study,
Int Angiol 2015;34(1):43-52.
[116] Bentzon JF, Otsuka F, Virmani R, et al (2014),
Mechanisms of plaque formation and rupture,
Circ Res 2014;114(12):1852-66.
[117] Sakakura K, Nakano M, Otsuka F, et al (2013),
Pathophysiology of atherosclerosis plaque progression,
Heart Lung Circ 2013;22(6):399-411.
[118] Belcaro G, Dugall M, Ippolito E, et al (2015),
Pycnogenol and Centella Asiatica for preventing asymptomatic atherosclerosis progression into clinical events,
Minerva Cardioangiol 2015 Oct 27.
[119] Belcaro G, Ippolito E, Dugall M, et al (2015),
Pycnogenol and Centella asiatica in the management of asymptomatic atherosclerosis progression,
Int Angiol 2015;34(2):150-7.
[120] Lorenz MW, Markus HS, Bots ML, et al (2007),
Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis,
Circulation 2007;115(4):459-67.
[121] Scott Fogle, ND (2016),
The Most Important Blood Tests Available for Assessing Cardiovascular Risk,
Life Extension Magazine May 2016, Ask the Doctor.
Atherosclerotic Plaque Formation [Links, Images, Papers, Patents, Books, LifeExtension]; Blood Tests [Links, Images, Papers, Patents, Books, LifeExtension]; Blood Tests for Cardiovascular Risk Assessment [Links, Images, Papers, Patents, Books, LifeExtension]; Nutraceuticals for LDL particle size control [Links, Images, Papers, Patents, Books, LifeExtension]; Techniques for LDL particle size control [Links, Images, Papers, Patents, Books, LifeExtension]; It is useful to know the number of LDL particles circulating in the blood [Links, Images, Papers, Patents, Books, LifeExtension]. A higher amount of smaller LDL particles is much more dangerous than a smaller amount of larger LDL particles. See small dense LDL versus large buoyant LDL [Links, Images, Papers, Patents, Books, LifeExtension]. Small dense LDL cholesterol more easily penetrates the blood vessel wall and starts the process of plaque formation. We have new blood testing technology for both particle count and the size of LDL particles [Links, Images, Papers, Patents, Books, LifeExtension]. "The best result you can get is a low particle count combined with large buoyant LDL. The worst result is a high particle count with small dense LDL, which is a very bad combination." The NMR LipoProfile Test [Links, Images, Papers, Patents, Books, LifeExtension] produces this information using nuclear magnetic resonance (NMR) spectroscopy for LDL testing [Links, Images, Papers, Patents, Books, LifeExtension] to directly measure particle count and size. "You want a low LDL-P (low LDL particle count), low small LDL-P (low small LDL particle count), and low LP-IR Score (low insulin resistance score) combined with a high HDL-P (high HDL particle count) and large LDL size for the lowest cardiovascular risk." Other kinds of blood testing are desirable, including: __Oxidized LDL testing [Links, Images, Papers, Patents, Books, LifeExtension]. __F2-Isoprostanes urine testing [Links, Images, Papers, Patents, Books, LifeExtension]. __MPO (myeloperoxidase) testing [Links, Images, Papers, Patents, Books, LifeExtension]. __MTHFR (methylenetetrahydrofolate reductase) gene testing [Links, Images, Papers, Patents, Books, LifeExtension]. ____Deals with methylation, folate metabolism, and homocysteine levels. __COMT (catechol-O-methyltransferase) testing [Links, Images, Papers, Patents, Books, LifeExtension]. ____Looks at how specific neurotransmitters are metabolized [Links, Images, Papers, Patents, Books]. __Arachidonic_Acid/EPA ratio test [Links, Images, Papers, Patents, Books, LifeExtension]. ___When the Arachidonic_Acid/EPA ratio is higher, there is preferred incorporation of AA into membranes over EPA, ___producing a pro-inflammatory environment. The optimal ratio of AA: EPA is around 1.7. |
[122] Filiberto Zadini, Giorgio Zadini, Original Assignee: Atheranova Operations, Inc. (2013),
Dissolution of arterial plaque US 20130029946 A1,
___[Papers, Patents, Books, LEF].
___ursodeoxycholic acid (UDCA) [Papers, Patents, Books, LEF].
___Serious adverse consequences can result from a x2 overdose. Sensitive stuff.
___Can dissolve gallstones and atherosclerotic plaque. Natually occurring. See Ursodiol.
___RELATED: LEF search on arterial plaque dissolution produces:
___Serrapeptase 10 mg 90 capsules: Solaray, Item# 28548.(0) Retail Price: $24.99.
_____Serrapeptase [Papers, Patents, Books, LEF]. Silkworm's coccoon dissolving enzyme.
_______Serrapeptase for arterial plaque dissolution [Papers, Patents, Books, LEF].
_______Serrapeptase: The natural anti-inflammatory, Life Extension Magazine, September 2003.
[123] Nadia Mason (2014),
Focus on Serrapeptase [Online],
Discover Nutrition November 1, 2014.
" Because of its ability to dissolve fibrin, serrapeptase has also been used to dissolve arterial plaque, fibrous blockages in clogged or hardened arteries. As serrapeptase only dissolves dead or damaged tissue, this could enable the dissolution of harmful atherosclerotic plaques without causing any harm to the inside of the arteries. Studies of serrapeptase supplementation have found positive benefits with a dosage of around 10mg, taken after meals three times daily. No long-term studies of this supplement have yet been conducted, although studies to date suggest that supplementation for a period of 4 weeks seems safe (1,2)."
|
___Serrapeptase 10 mg 90 capsules: Solaray, Item# 28548.(0) Retail Price: $24.99.
_____Serrapeptase [Papers, Patents, Books, LEF]. Silkworm's coccoon dissolving enzyme.
_______Serrapeptase for arterial plaque dissolution [Papers, Patents, Books, LEF].
_______Serrapeptase: The natural anti-inflammatory, Life Extension Magazine, September 2003.
[124] Dr. H A Nieper - Germany (),
Silk Worm Enzymes For Carotid Artery Blockage [OnLine].
"Serapeptase is a stronger saseinolytic (fibrinolytic) agent than any other known alkaline or neutral protease such as bromelain or pronase."
___See Serapeptase as a fibrinolytic agent [Papers, Patents, Books, LEF].
___Bromelain as a fibrinolytic agent [Papers, Patents, Books, LEF; Index/Bromelain].
___Pronase as a fibrinolytic agent [Papers, Patents, Books, LEF].
[125] George E. Felton (1980),
Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients [Online],
Medical Hypotheses Volume 6, Issue 11, November 1980, Pages 1123-1133.
"Bromelain plasminogen activator will produce plasmin in rat experiments... Since bromelain therapy leads to formation of platelets with increased resistance to aggregation, it is obvious that the dominant endogenous prostaglandins being produced must be from the group that increases platelet cyclic AMP levels (prostacyclin, PGE1, etc.). The combination of fibrinolytic and antithrombic properties appear to be effective and two large scale tests on heart patients have shown a practically complete elimination of thrombosis."
|
[126] Pierro Francesco Di (2014),
Fibrinolytic compositions comprising bromelain and nattokinase for the prevention and treatment of phlebothrombotic states, WO 2014079689 A1, May 30, 2014.
[127] William Faloon (2015),
Live Longer By Changing How You Cook!,
Life Extension Magazine August 2015. [AGEs, Carcinogens].
[128] Hansson GK, Robertson AK, Soderberg-Naucler C (2006),
Inflammation and atherosclerosis,
Annu Rev Pathol 2006;1:297-329. [Inflammation].
[129] Libby P, Ridker PM, Maseri A (2002),
Inflammation and Atherosclerosis,
Circulation 2002;105(9):1135-43. [Inflammation].
[129] Covas MI, Nyyssonen K, Poulsen HE, et al. (2006),
The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial,
Ann Intern Med 2006;145(5):333-41.
[130] Covas MI (2007),
Olive oil and the cardiovascular system,
Pharmacol Res 34. 2007;55(3):175-86.
[131] Bendinelli B, Masala G, Saieva C, et al. (2011),
Fruit, vegetables, and olive oil and risk of coronary heart disease in Italian women: the EPICOR Study,
Am J Clin Nutr 2011;93(2):275-83.
[132] Estruch R, Ros E, Salas-Salvado J, et al. (2013),
Primary prevention of cardiovascular disease with a Mediterranean diet,
N Engl J Med 2013;368(14):1279-90.
[133] Dimitriou M, Rallidis LS, Theodoraki EV, et al. (2016),
Exclusive olive oil consumption has a protective effect on coronary artery disease; overview of the THISEAS study,
Public Health Nutr 2016;19(6):1081-7.
[134] Qureshi AA, Sami SA, Salser WA, et al. (2002),
Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans,
Atherosclerosis 2002;161(1):199-207. [Tocotrienols].
[135] Tan DT, Khor H, Low W, et al. (1991),
Effect of a palm-oil-vitamin E concentrate on the serum and lipoprotein lipids in humans,
The American journal of clinical nutrition 1991;53(4):1027S-30S. [Tocotrienols].
[136] Baliarsingh S, Beg ZH, Ahmad J (-),
The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia,
Atherosclerosis 182(2):367-74.
[137] Qureshi AA, Bradlow BA, Brace L, et al. (1995),
Response of hypercholesterolemic subjects to administration of tocotrienols,
Lipids 1995;30(12):1171-7.
[138] Mendelsohn Andrew R. and Larrick James W. (2015),
Telomerase Reverse Transcriptase and Peroxisome Proliferator-Activated Receptor ? Co-Activator-1a Cooperate to Protect Cells from DNA Damage and Mitochondrial Dysfunction in Vascular Senescence [Abstract PDF],
Rejuvenation Research October 2015, 18(5): 479-483.
"Alpha lipoic acid (ALA) stimulated expression of PGC-1a and TERT and reversed DNA damage, vascular senescence, and atherosclerosis, similarly to ectopic expression of PGC-1a. ALA stimulated cyclic adenosine monophosphate (cAMP) signaling, which in turn activated the cAMP response element-binding protein (CREB), a co-factor for PGC-1a expression. The possibility that ALA might induce TERT to extend telomeres in human cells suggests that ALA may be useful in treating atherosclerosis and other aging-related diseases."
|
[139] Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS (2002),
Pathogenesis of atherosclerosis: A multifactorial process,
Exp Clin Cardiol 2002 Spring;7(1):40-53.
[140] William Faloon (2007),
A Lethal Misconception of Epidemic Proportion,
Life Extension Magazine May 2007. William Faloon on homocysteine and heart disease.
[285] Dwyer JH, Paul-Labrador MJ, Fan J, Shircore AM, Merz CN, Dwyer KM (2004),
Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles Atherosclerosis Study,
Arterioscler Thromb Vasc Biol 2004 Feb;24(2):313-9.
Lutein and zeaxanthin inhibit the development of carotid intima-media thickness, thus signaling inhibition of atherosclerosis.
[286] Baynes JW, Thorpe SR (2000),
Glycoxidation and lipoxidation in atherogenesis,
Free Radic Biol Med 2000;19. 28(12):1708-16. [Atherogenesis, Glycoxidation, Lipoxidation].
[287] Rashid I, van Reyk DM, Davies MJ (2007),
Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro,
FEBS Lett 2007;581(5):1067-70. [Foam Cell Formation in Atherosclerosis, Carnosine].
[288] Brown BE, Kim CH, Torpy FR, et al. (2014),
Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E(-/-) mice,
Atherosclerosis 2014;232(2):403-9. [Carnosine, Diabetes].
[289] Zhang L, Zhou G, Song W, et al. (2012),
Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo,
Apoptosis 2012;17(1):25-36.
[290] Michael Downey (2017),
Arterial Plaque Rupture,
Life Extension Magazine May 2017.
___Gotu Kola improves the stability of soft atherosclerotic plaque
___by improving the expression of collagen.
___French maritime pine bark extract (150 mg) plus Gotu Kola (225 mg) improves soft plaque stability best.
[291] Luzzi R, Belcaro G, Ippolito E (2016),
Carotid plaque stabilization induced by the supplement association Pycnogenol(R) and centella asiatica (Centellicum(R)),
Minerva Cardioangiol 2016;64(6):603-9. [Pycnogenol, Pine Bark Extract, Gotu Kola].
[292] Cheruvu PK, Finn AV, Gardner C, et al. (2007),
Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study,
J Am Coll Cardiol 2007;50(10):940-9.
[293] Miyazawa T, Nakagawa K, Shimasaki S, et al. (2012),
Lipid glycation and protein glycation in diabetes and atherosclerosis,
Amino Acids 2012;42(4):1163-70.
[294] Saffi MA, Furtado MV, Polanczyk CA, et al. (2015),
Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article,
World J Cardiol 2015;7(1):26-30.
[295] Osika W, Dangardt F, Gronros J, et al. (2007),
Increasing peripheral artery intima thickness from childhood to seniority,
Arterioscler Thromb Vasc Biol 2007;27(3):671-6.
[296] Kolodgie FD, Burke AP, Farb A, et al. (2001),
The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes,
Curr Opin Cardiol 2001;16(5):285-92.
[297] Glycation and glycoxidation of low-density lipoproteins by glucose. (fill out).
[298] Paul M Ridker, M.D., Brendan M. Everett, M.D., Tom Thuren, M.D. et. al. (2017),
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease,
The New England Journal of Medicine, August 27, 2017, DOI: 10.1056/NEJMoa1707914. [Canakinumab].
[299] Navab M, Ananthramaiah GM, Reddy ST, et al. (2004),
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL,
J Lipid Res 2004;45(6):993-1007.
[300] Wang JC, Bennett M (2012),
Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence,
Circ Res 2012;111(2):245-59.
[301] Kearns CE, Schmidt LA, Glantz SA (2016),
Sugar Industry and Coronary Heart Disease Research: A Historical Analysis of Internal Industry Documents,
JAMA Intern Med 2016;176(11):1680-5.
[302] McGandy RB, Hegsted DM, Stare FJ (1967),
Dietary fats, carbohydrates and atherosclerotic vascular disease,
N Engl J Med 1967;277(4):186-92 contd.
[303] McGandy RB, Hegsted DM, Stare FJ (1967),
Dietary fats, carbohydrates and atherosclerotic vascular disease,
N Engl J Med 1967;277(5):245-7 concl.
[304] Danaei G, Lawes CM, Vander Hoorn S, et al. Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment,
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[305] Hamerman D (2005),
Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies,
Qjm 2005;98(7):467-84.
[306] Toma I, McCaffrey TA (2012),
Transforming growth factor-beta and atherosclerosis: interwoven atherogenic and atheroprotective aspects,
Cell Tissue Res 2012;347(1):155-75.
[307] Hamerman D (2005),
Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies,
Qjm 2005;98(7):467-84.
[308] Toma I, McCaffrey TA (2012),
Transforming growth factor-beta and atherosclerosis: interwoven atherogenic and atheroprotective aspects,
Cell Tissue Res 2012;347(1):155-75.
[309] William Faloon (2009),
The Cholesterol Controversy, Life Extension Magazine, Feb 2009.
"Perhaps no other nutrient has demonstrated better anti-LDL oxidation effects than pomegranate. In a clinical study, human subjects taking pomegranate showed a beneficial 35% reduction in carotid intima-media thickness accompanied by a 45% improvement in carotid blood flow. As evidenced by the chart above, pomegranate improved markers related to LDL oxidation by up to 130%!" [6]. [LDL peroxidation, Pomegranate].
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[310] Michael Ozner, MD (2018),
Life Extension Magazine (Interview: Ask The Doctor) February 2018.
Links/Atherogenic Lipoproteins, Images, Video, Papers, Patents, Books, LifeExtension; The apolipoprotein B (apo B) blood test [Patents, Books, LEF] measures the number of potentially dangerous particles that can lead to atherosclerois [Patents, Books, LEF]. A second test, the LDL-P test [Patents, Books, LEF], can also be used since it measures the total number of LDL particles [Patents, Books, LEF]. |
CMV (Cytomegalovirus)
[Index, Wikipedia/Cytomegalovirus, Links, Images, Video, Papers, Patents, Books, LEF;
Virology, Virology/Virus Table, Glioma, Brain Cancer; AplasticAnemia, anemia[39]].
"HCMV is found throughout all geographic locations and socioeconomic groups, and infects between 50% and 80% of adults in the United States (40% worldwide) as indicated by the presence of antibodies in much of the general population. Seroprevalence is age-dependent: 58.9% of individuals aged 6 and older are infected with CMV while 90.8% of individuals aged 80 and older are positive for HCMV". - Wikipedia. "One study found a 42% increase in the annual death rate among older adults with CMV compared to those without, corresponding to a 3.7-year reduction in life expectancy after age 65" (73). [], []."
Cytomegalovirus (CMV) is a herpes-family virus [virus table]. CMV (cytomegalovirus) viral infection [Links] devours resources of the immune system in elderly victims, although its visible effects may be minimal at first. This causes the CMV viral pathogen to be impacting in immunosenescence. CMV viral infection is widespread in many populations. "Chronic CMV infection is associated with frailty, cognitive decline, and arterial occlusion." - William Faloon [1]. Consider the effect of cytomegalovirus on telomere length [Images, Papers]. CMV also turns out to be a key element in glioma brain cancers. 1,000 Americans die every month from incurable glioblastoma, for which survival averages 15 months. Valganciclovir has extended survival to over four years [11], [12]. |
Animal Virus Family | Typical Member | Genome Size (kbp) | Cures showing antiviral activity |
Herpesviruses [Index] | Cytomegalovirus (CMV) ___(DNA genome) ___Glioma, ___Glioblastoma multiforme |
235 | Garlic [Index, Ref, Images], Glycyrrhizin [Index, Ref, Images], St. John's Wort [Index, Ref] Hypericin from St.John's Wort, Natural Killer cell boosters, ___Active hexose correlated compound (AHCC), ___Alpha Lipoic Acid, ___Arabinoxylin, ___Beta carotene, ___Chronic resistance exercise training, ___Cistanche, ___Curcumin, ___Garlic, ___Genistein, ___Ginseng, ___Lentinan, ___Mistletoe, ___More… |
See Virology/Virus Table, which displays some nutraceutical cures for CMV, and CMV vaccine development. Note that some herpes viruses are treatable with eugenol from cinnamon. Garlic and glycyrrhiza (the source of licorice) can be used to treat CMV. St. John's Wort is active against cytomegalovirus via hypericin, a constituent of St. John's wort. Natural Killer cell boosters are also valuable in fighting CMV. Valganciclovir [Papers, Patents, Books, LifeExtension] is also prescribed to treat cytomegalovirus [11]. "We conclude that the (TA-65 Patton Protocol) protocol lengthens critically short telomeres and remodels the relative proportions of circulating leukocytes of CMV+ subjects toward the more “youthful” profile of CMV- subjects." [7].
References [1] William Faloon (2015), A Common Virus, Life Extension Magazine, Jan 2015. [2] Aubrey de Grey and Michael Rae, Ending Aging, pp.209-215, material on CMV. [3] Lisa Antone (2014), Common Virus Links to Deadly Brain Cancer with preamble by William Faloon, Life Extension Magazine, February 2014. [Glioma] [4] Shiraki K, Yukawa T, Kurokawa M, Kageyama S (1998), Cytomegalovirus infection and its possible treatment with herbal medicines, Nihon Rinsho 1998 Jan;56(1):156-60. [Cures for CMV (Patents, Books, LEF); Garlic; Viral Cures]. [5] Duplicate. [6] Tsoukas P. (2012), Immune senescence and cardiovascular morbidity as a result of chronic cytomegalovirus infection, RCSIsmj 2012;5:67-70. [7] Calvin B. Harley, Weimin Liu, Maria Blasco, Elsa Vera, William H. Andrews, Laura A. Briggs, and Joseph M. Raffaele (2010), A Natural Product Telomerase Activator As Part of a Health Maintenance Program, Rejuvenation Research, September 7, 2010. [8] Savva GM, Pachnio A, Kaul B, et al. (2013), Cytomegalovirus infection is associated with increased mortality in the older population, Aging Cell 2013 Jun;12(3):381-7. [9] Kanapeckiene V, Kalibatas J, Redaitiene E, Ceremnych J (2007), The association between cytomegalovirus infection and aging process, Medicina (Kaunas) 2007;43(5):419-24. [10] Salem ML, Hossain MS (2000), Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection, Int J Immunopharmacol 2000 Sep;22(9):729-40. [11] William Faloon (2015), Major Advances In Glioblastoma Treatment, Life Extension Magazine September 2015.
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Posted on: Jul 07, 2019 at 4:27 PM
I see signs of life regarding Craig Stewart these days here. I recently turned 70 myself (birthday photo below, May 13, 2019, at the WSU RSC Starbucks Coffee Shop). I hope everything is going very well for you and your career as a popular musician. I remember your fine performances online and at the 40th class reunion.
My 70th birthday came on May 13, 1949. The pictures below were taken in the WSU RSC center Star Bucks Coffee shop at the time. Some brown hair dye here. The pics were made with an Internet cell phone, the Alcatel Raven LTE A574BL.
Medicine: Astragalus (33 grams/day, 15 days/month or more) for telomerase activation and Natural Killer cell promotion, along with tissue-regenerative Retinol (Vitamin A) (50 caps/day) this month. We suspect the high NK cell promotion due to astragalus reduces the number of proinflammatory senescent cells in order to devour precancerous cells. Stopping the astragalus results in faster-than-expected aging probably due to this NK cell effect. Arginine was taken at 5 grams/day for 15 days of nitric oxide, which acts as a telomerase activator to promote telomere growth in the cells of the vascular endothelium. Hawthorn, a vascular smooth muscle tonic and another telomerase activator, was taken at 7x750 mg/day to tone up smooth muscle cells in the vascular sheath, which helps to treat varicose veins and put in another source of telomerase activation. In addition, Life Extension skin-restoring Ceramides were taken at 1 cap/day for better skin hydration and wrinkle removal, and Vitamin K2 was taken at 200 mcg/day to combat vascular calcification and general ossification of tissues. I think I have seen a case recently in which ossification of ligaments in the neck was relieved by heavy application of vitamin K2 in a way that corrected neck pain that would otherwise have led to expensive surgery. The man seemed to be suffering from a vitamin K2 deficiency from avoiding hard cheeses, which contain plenty of vitamin K2 menaquinones that prevent ossification by calcification and hardening of the heart and the vascular system. I took also neuroregenerative vitamin B12 (10-15 mg/day) to prevent Alzheimer's Disease, and added some exercise (pullups, tricep presses, ect.) for improved brain circulation, telomerase activation, nitric oxide, growth factors, better NK cell levels, and AMPK activation for better cellular autophagy and fat reduction. I took whey protein shakes for muscle mass (leucine from whey drives the mTOR muscle synthesis pathway) and texas ruby red grapefruit juice (an AMPK activator) for definition, with salmon, tuna, or white crab meat for growth. AMPK activators promote cellular autophagy and kick fat and other wastes out of cells. Pomegranate juice (also an AMPK activator and a telomerase activator) was taken daily to prevent atherosclerosis, and it was attempted to rely more on fish than meat to reduce LDL cholesterol from saturated fat, which turns into oxidized LDL that attacks the vascular endothelium to initiate atherosclerosis when combined with sugar for glycoxidation of LDL cholesterol. Glycoxidation of LDL cholesterol produces oxidized LDL cholesterol, the primary cause of atherosclerosis. Staying lean reduces atherosclerosis from C-reactive protein, which goes up in very overweight specimens. I also use an Aloe Vera skin cream. I think this makes a great personal lubricant when combined with the right amount of finely chopped garlic to stop HPV infections that can produce cervical cancer, an old Arab idea for deodorized garlic hot lubes to save a darling like Farah Fawcett with and escape the tally-ho of sin unscathed for the remission of sins. 1,2,3...Infinity. It may be adequately spermicidal, too. Check on Google and at http://www.lef.org/magazine . Fine chopped garlic and fine chopped onions are lilies of the field with wonderful antibiotic and anticancer properties. I used fine chopped garlic at 3-5 cloves per serving, 3 servings per day (served in a salad on crackers) to defeat abcessed teeth and a facial infection in just 3-5 days. Only 4 cloves of garlic may be taken this way continuously for years, however, in order to avoid liver problems. See Hullquist's book on garlic, which also lengthens telomeres and prevents fatty streaks associated with early-stage atherosclerosis, the primary killer of Americans. It seems garlic shows activity against all bacterial, viral, fungual, and yeast pathogens that plaque sexually active adults and sometimes lead to tragic anemia, and perhaps to expensive bone marrow transplants. It seems to defeat all pathogen cells without cellular nuclei, while leaving cells with cellular nuclei (like your cells) alone when applied at the correct dose. So regular garlic purges have been popular where sexual activity was high, although the odor of garlic is quite an effective sex repellant. Mints and so forth are available for garlic breath control, however. Garlic was standard issue to the Red Army in World War II, famous as "Russian Penicillin", and sometimes even shown sculpted on church steeples like St. Basil's in Moscow,
like good news from Jesus of Nazareth, who encouraged us to consider the lilies of the field. Chopped garlic cures leprosy, polio, the Black Death, bubonic plaque, yellow fever, but.... "see that no man knows it" comes out of Jesus sometimes with respect to cures, according to the New Testament, as it might from a country doctor and faith healer somewhat unsure of his methods. I suppose chopped garlic worked more impressively than rubbing mud in the eyes of the blind most of the time, which must have been most displeasing when it failed. Lazarus was covered with sores, probably due to an infection treatable with garlic. A cured man formerly covered with sores could probably come out of a death house. I might add that eating crushed garlic works well on fistula abscesses, ulcerative colitis, and Crohn's Disease, so that it can fix some of the most embarrassing and painful consequences of sin. In the 21st Century, Internet searches on garlic cures are easily formulated through a world library of scholarly papers, patents, books, and Life Extension Magazine. I have checked quite a volume of them, myself.
Below: Three photos of Father Green at 70 (produced artist and teacher Dyan, from 1st wife Susan, KS). https://www.youtube.com/watch?v=5j-12s2HgOc . https://dyangreen.com/news.html .
I have a couple of photos of myself taken on Mother's Day, May 12, 2019, the day before my 70th birthday today, May 13, 2019. I used Life Extension skin-restoring ceramides
to improve my old boy act, and also 33 grams/day of astragalus extract for 2 weeks out of each month, tending to produce a de-aging effect of about -5 years/year. I also take 50 caps (a half a bottle) of tissue-regenerative vitamin A every day, as recommended by Donald Trump, The President of the United States, who may take more. To take more vitamin A (retinol), I have to take the 2nd half of the bottle later in the day. To get my height up a bit amid the thundering rush of new troops on the street, I take white crab meat. I could get it up to 6'1" for a while, but you must keep taking some. So now I'm getting it back up again with another white crab meat experiment. I also take hawthorn at 7 caps/day, 750 mg/cap, which is a great smooth muscle toner and telomerase activator. I might improve hawthorn results by taking more. I also get 5 grams of arginine per day to apply nitric oxide as a telomerase activator to the cells of the vascular endothelium. I get pomegranate juice to ward off atherosclerosis otherwise. It is also an AMPK activator that reduces body fat and a telomerase activator. Vitamin B12 at 5-10 mg per day is taken to prevent Alzheimer's and provide neuro-regeneration for the brain. Atherosclerosis is the number 1 killer of Americans and it usually comes from eating sugar with saturated fat, producing glycoxidation of LDL cholesterol from the fat, that attacks the vascular endothelium with oxidized LDL cholesterol, leading to atherosclerosis. Prefer fish without saturated fats to avoid atherosclerosis, and use artificial sweeteners. Serrapeptase, the enzyme a silkworm uses to destroy its cocoon, can be used to wipe out all the atherosclerotic plaque in your body, tending to eliminate angina, heart attack, and stroke. Read up on preventive medicine for elders at Life Extension Magazine at http://www.lef.org/magazine , which features over 20 years of valuable back issues. Use Natural Killer cell boosters like astragalus, garlic, and shiitake mushrooms to keep yourself free of cancer. Natural killer cells attack cancer cells. Cancer is the 2nd worst killer of Americans, as I recall. With Internet, you should be able to figure out all of the cures to all of the causes of death and choose accordingly until you never do go down. It is good to keep exercising, as chronic exercise improves Natural Killer cell count and activity. Good luck at tracking down everything you need to know before you keel over sideways from waiting for your doctor to mention it. Looking forward to 2020. Photos WSU RSC Center.